<sup>1</sup>H-NMR metabolomics for wine screening and analysis

The number of metabolomic studies has grown steadily over the last twenty years. Among fields application, food sciences are broadly represented. Proton NMR (1H-NMR) is a commonly used technique for metabolomics and particularly suitable wine analysis, because major constituents highly dependent on biotic abiotic conditions. 1H-NMR-based were first to guarantee authenticity wines, more recently determine impact viticultural or oenological practices using both targeted untargeted protocols. This state-of-the-art review covers different analytical methodologies developed ensure traceability from sample preparation 1H-NMR spectrum analysis. potential applications spectroscopy in oenology, control monitoring winemaking, described. challenges perspectives deployment also discussed.